Cheap Flights from Des Moines to Panama City

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Find the cheapest month or even day of the year to fly to Panama City

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Find the cheapest month to fly from Des Moines to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Panama City flights are currently cheapest in November.

Alternative Des Moines to Panama City routes

Looking for the cheapest, fastest or easiest route from Des Moines to Panama City? You could fly into the following airports instead.

Des Moines to Panama City: Flight information

The things to know before you go.
Cheapest flight foundRs55,496
Cheapest month to flyNovember

Finding cheap flights from Des Moines to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Des Moines to Panama City is Rs127,862. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Panama City. But we found flights with one or more stops from Rs127,862.
As of September 2025, there are no flights flying from Des Moines to Panama City.
The cheapest month to fly from Des Moines to Panama City is usually November.
If you're flying from Des Moines Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from Rs127,862.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Panama City on Tuesday, 11 November 2025.
No airlines currently offer direct flights between Des Moines Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In September, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, United offers the cheapest flight tickets to Panama City.

Flying from Des Moines International Airport (DSM) to Panama City: what you need to know

  • Panama City and Des Moines (where Des Moines International Airport is located) share the UTC-5 timezone. That means there's no time difference to consider.

  • For a smooth journey, arrive at the airport two hours ahead of international flights and an hour before domestic departures. This will give you plenty of time to board your DSM to Panama City flight.

  • Taking off during a peak period like school or public holidays? Expect longer lines at security and check-in. Give yourself extra leeway and arrive up to four hours before international flights and two hours before domestic departures.

  • We make it a breeze to book flight tickets from DSM to Panama City with a stopover. To see the options, deselect 'Direct flights only.' Then, select a flight offering a stop long enough to explore your chosen city. Popular stopovers include:

    • Hartsfield-Jackson Atlanta International Airport (ATL)

    • George Bush Intercontinental Airport (IAH)

    • Miami International Airport (MIA)

  • DSM is about 6 kilometres from central Des Moines. If you're catching a cab, ride-sharing or driving from the centre, it'll take you 15 minutes or so to get there, depending on traffic conditions. If you're taking public transport, expect the journey time to be around 45 minutes.

  • In search of a hotel close to DSM? If you've booked an early flight from Des Moines International Airport to Panama City, these accommodation options will put you moments from check-in:

  • 80.45% of flights departing from Des Moines International Airport arrive at their destination on schedule. Given its impressive on-time stats, delays are unlikely when flying out of DSM.

  • You'll find DSM at 5800 Fleur Drive, Suite 201.

How to find the cheapest flights from Des Moines International Airport (DSM) to Panama City

  • Rs55,496 is currently the lowest price for a one-way Des Moines International Airport to Panama City flight. A return flight ticket starts from Rs127,862. These fares may change depending on demand.

  • Don't leave things to the last minute. You're more likely to find cheap flights from DSM to Panama City if you book early. Airlines often have some fantastic early bird discounts.

  • Finding cheap tickets from Des Moines International Airport to Panama City is more likely if you can be flexible with your travel dates. Use the 'Whole month' tool to get the lowest prices across the month and pick up a fantastic deal.

  • There's no need to check back constantly to see if fares have dropped when you create a Price Alert. We'll notify you as soon as there's an updated deal for cheap flights from DSM to Panama City.

  • Choose your preferred departure and arrival times, number of stops and airlines with our filters. Then, sort the results for your flight from Des Moines International Airport to Panama City by 'Cheapest,' 'Best' or 'Fastest.'

Airports in Panama City

Tocumen International Airport (PTY)

  • Tocumen International Airport (PTY) is around 21 kilometres from central Panama City. If you're getting a cab or a ride-share, the drive takes roughly 20 minutes.

  • Getting there by public transport will take you around 1 hour 5 minutes.

  • If you're coming in on a late flight from Des Moines International Airport to Panama City, few things beat the convenience of staying close to the terminal. Pick up your bags from the carousel and then be showered and sleeping soon after at one of these hotels near PTY:

  • Go wherever you want, whenever you want with a Tocumen International Airport rental car. Book your wheels from Avis, Dollar or MEX and find adventure across Panama City and beyond.

  • Lock in the best rate by reserving your ride from Tocumen International Airport around three weeks in advance of your flight from DSM to Panama City.

Marcos A. Gelabert International Airport (PAC)

  • Marcos A. Gelabert International Airport (PAC) is about 2 kilometres from central Panama City. Once you've hopped off your flight from Des Moines International Airport to Panama City, it'll take you around 5 minutes to get to the heart of the city in a ride-share or cab.

  • If you choose to travel on public transport, you'll get to the city centre in 25 minutes or so.

  • Place the 'Do not disturb' sign on your door and unwind at a hotel near PAC. Here are a few options where you can check in after your DSM to Panama City flight:

  • Thrifty, Avis and Alamo make picking up a Marcos A. Gelabert International Airport rental car quick and easy. These providers are located in or around the terminal and will have you on the road before long.

  • Lock in the best price by securing your ride from PAC three weeks ahead of time. You'll also have access to a greater selection of vehicles.

Panama Pacifico Airport (BLB)

  • Find your way to the city centre after your flight from Des Moines International Airport to Panama City has touched down. Central Panama City is about 16 kilometres from Panama Pacifico Airport (BLB) and takes roughly 20 minutes to reach by car.

  • Check in to a hotel close to BLB and go from the plane to your bed in a flash. Whether you're coming in on a late DSM to Panama City flight or just want a stress-free arrival, these accommodation options offer a quick route to a good night's sleep:

  • Whether you'd like a compact for a solo trip or a spacious SUV to fit everyone and their gear, you'll find the ideal Panama Pacifico Airport rental car for you. Explore the types of wheels available from suppliers such as Sixt, Dollar and Thrifty.

  • If you're after a specific kind of vehicle, book your ride from BLB around one week before your flight from Des Moines International Airport to Panama City. This gives you a better shot at getting your preferred car, as well as a better deal.

Best time to go to Panama City

  • Visit Panama City in high season if you prefer a lively atmosphere, but remember that prices are generally higher. Alternatively, book your flights from Des Moines International Airport to Panama City in the low season when prices are cheaper and it's not as busy.

  • Lock in a Des Moines International Airport to Panama City flight ticket with a departure in March if you're eager to explore the city during its warmest month. Expect temperatures to range from 21ºC to 32ºC.

  • Search for cheap tickets from DSM to Panama City in February if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

  • After booking your flight from Des Moines International Airport to Panama City, find a hotel that keeps you close to what you want to see. Make one of these accommodation options your base for exploring Panama City:

  • All great journeys should include some sightseeing. Casco Viejo, Panama Canal Museum and Cinta Costera are must-visits when exploring Panama City.

Explore more of Panama

  • Panama City is easy to fall in love with, but there are so many other parts of Panama waiting to be discovered. Around 322 kilometres west of Panama City, a trip to David will keep you busy. Start with attractions like Parque Cervantes, Altos del Rio Park and Coquito Hills Park.

  • If you're looking to explore another major destination in Panama, head for Santiago de Veraguas, about 193 kilometres south-west of Panama City. Santiago the Apostle Cathedral, Santiago de Veraguas, The Church of Jesus Christ of Latter Day Saints and La Placita San Juan De Dios are highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.