Cheap Flights from Des Moines to Greenville-Spartanburg

Compare Des Moines to Greenville-Spartanburg flight deals

Find the cheapest month or even day of the year to fly to Greenville-Spartanburg

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Flight deals from Des Moines to Greenville-Spartanburg

Looking for a cheap last-minute deal or the best return flight from Des Moines to Greenville-Spartanburg? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Des Moines to Greenville-Spartanburg

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Greenville-Spartanburg flights are currently cheapest in January.

Des Moines to Greenville-Spartanburg: Alternative routes

Compare routes from Des Moines to Greenville below. You may find an airport to fly into that's cheaper, faster, or easier than Greenville-Spartanburg.

Des Moines to Greenville: Flight information

The things to know before you go.
Cheapest flight foundRs44,633
Cheapest month to flyJanuary

Finding cheap flights from Des Moines to Greenville-Spartanburg: Frequently asked questions

The best price we found for a return flight from Des Moines to Greenville-Spartanburg is Rs107,478. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Des Moines to Greenville-Spartanburg. But we found flights with one or more stops from Rs107,478.
As of November 2025, there are no flights flying from Des Moines to Greenville-Spartanburg.
The cheapest month to fly from Des Moines to Greenville-Spartanburg is usually December.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Greenville-Spartanburg Airport on Tuesday, 30 December 2025.
No airlines currently offer direct flights between Des Moines Airport and Greenville-Spartanburg Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Greenville-Spartanburg but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
Currently, Allegiant Air offers the cheapest flight tickets to Greenville-Spartanburg.

Flying from Des Moines International Airport (DSM) to Greenville-Spartanburg International Airport (GSP): what you need to know

  • For a smooth journey, arrive at the airport two hours ahead of international flights and an hour before domestic departures. This will give you plenty of time to catch your DSM to GSP flight.

  • Flying during a peak time such as July? Major public holidays and other high seasons can mean longer lines at check-in and security. Play things extra safe and arrive up to four hours before international flights and two hours before domestic departures.

  • We make it a breeze to book a flight with a stopover. To see all your options for tickets from Des Moines International Airport to Greenville-Spartanburg International Airport, deselect 'Direct flights only.' Then, pick a flight with a stop long enough to explore your chosen city. Some great stopovers between DSM and GSP include:

    • Charlotte Douglas International Airport

    • Hartsfield-Jackson Atlanta International Airport

    • O'Hare International Airport

How to find the cheapest flights from Des Moines International Airport (DSM) to Greenville-Spartanburg International Airport (GSP)

  • Rs44,633 is the best price for a one-way Des Moines International Airport to Greenville-Spartanburg International Airport flight. Return flights start from Rs107,478. These fares can change based on demand.

  • It's usually best to book early if you want to get cheap tickets from DSM to GSP. That's because airlines adjust prices based on demand, which tends to rise closer to the date of departure.

  • The 'Whole month' tool shows you the cheapest flights from Des Moines International Airport to Greenville-Spartanburg International Airport across every month. It's an easy way to find a bargain if your plans are flexible.

  • Picking up cheap flights from DSM to GSP is a piece of cake with Price Alerts. Simply set up one of these automatic alerts and we'll let you know when a new discounted fare appears.

  • Secure the perfect flight for you by using the filters. To see the 'Best,' 'Cheapest' or 'Fastest' flights from Des Moines International Airport to Greenville-Spartanburg International Airport, use the 'Sort by' function. You can also filter by airline, arrival and departure times, and journey duration.

Handy information about Des Moines International Airport (DSM)

  • DSM is located at 5800 Fleur Drive, Suite 201.

  • Des Moines International Airport gets high marks for its on-time performance. 80.45% of flights that depart DSM land on time.

  • Des Moines International Airport is about 10 kilometres from central Des Moines. If you're catching a cab, ride-sharing or driving from the centre, it'll take 15 minutes or so to arrive, depending on the traffic.

  • The journey on public transport will take about 45 minutes.

  • Get your travels off to a hassle-free start by staying near DSM. Whether you're catching an early flight from Des Moines International Airport to Greenville-Spartanburg International Airport or want to avoid feeling rushed, these hotels are the answer:

Arriving at Greenville-Spartanburg International Airport (GSP)

Getting from Greenville-Spartanburg International Airport (GSP) to central Greenville

  • GSP is located at 2000 GPS Drive, Suite 1.

  • Greenville-Spartanburg International Airport to the centre of Greenville has a drive time of about 20 minutes. It's approximately 27 kilometres away.

When to fly to Greenville-Spartanburg International Airport (GSP)

  • The quietest month for a flight from Des Moines International Airport to Greenville-Spartanburg International Airport is February, while August is the busiest. Pick the ideal time to go to Greenville based on whether you prefer a more fast-paced or easygoing experience.

  • Before locking in your flight from Des Moines International Airport to Greenville-Spartanburg International Airport, think about the type of weather you enjoy. July is the warmest month in Greenville, with the temperature ranging from 19ºC to 34ºC.

  • If you want to travel in cooler conditions, look for a cheap ticket from DSM to GSP in January. Average temperatures are between -3ºC and 13ºC then.

Explore more of United States

  • Greenville has plenty to offer, but there are so many other parts of United States you should also see. Around 145 kilometres east of Greenville, a visit to Charlotte will keep you on the move. Don't miss top attractions like NASCAR Hall of Fame, Freedom Park and Carolinas Aviation Museum.

  • Nashville is another must-experience destination in United States and is around 418 kilometres west of Greenville. No journey is complete without experiencing Grand Ole Opry, Country Music Hall of Fame and Museum and Ryman Auditorium.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.